The wrong questions

Right answers, wrong questions in clinical research.

To ensure that clinical research arrives at the "right" answers to the right questions for patients, studies should be designed to more closely approximate real-world use of therapeutics and devices.

Wrong questions, wrong answers? Are we getting the drugs we need?

This is a pre-copyedited, author-produced PDF of an article accepted for publication in Clinical Pharmacology & Therapeutics following peer review. The definitive publisher-authenticated version Lipworth W, Kerridge I, Day R. 2012. Wrong questions, wrong answers? Are we getting the drugs we need? Clinical Pharmacology & Therapeutics. 91 3, 367–369 is available online at http://www.nature.com/cl...

Could exposure assessment problems give us wrong answers to nutrition and cancer questions?

Whether fruits and vegetables provide protection from cancer is of considerable public health importance—but it remains an open question. In this issue of the Journal, Hung et al. report findings from two cohort studies: fruit and vegetable intake is associated with a “modest” reduction in risk of noncommunicable (“chronic”) disease (1). This reduction is confined to cardiovascular disease. The...

Wrong-side/wrong-site, wrong-procedure, and wrong-patient adverse events: Are they preventable?

HYPOTHESIS Wrong-side/wrong-site, wrong-procedure, and wrong-patient adverse events (WSPEs) are devastating, unacceptable, and often result in litigation, but their frequency and root causes are unknown. Wrong-side/wrong-site, wrong-procedure, and wrong-patient events are likely more common than realized, with little evidence that current prevention practice is adequate. DESIGN Analysis of se...

Inside the Wrong Body